Disclaimer: This information is not a substitute for professional medical advice, diagnosis or treatment.
Lion’s Mane mushroom (Hericium erinaceus) has long been revered in traditional Chinese and Korean medicine, believed to offer cognitive and neurological benefits. Recent scientific research is exploring its potential role in supporting cognitive function and healthy brain ageing.1 As the scientific community continues to explore the potential benefits of Lion’s Mane, let’s uncover what the research says so far.
What is Lion’s Mane?
Lion’s Mane is a distinctive, white, shaggy mushroom that resembles a lion’s mane as it grows—hence its name. Native to North America, Europe, and Asia, it has been used for centuries in traditional Chinese and Japanese medicine for its potential health benefits. Often consumed as a supplement, tea, or culinary ingredient, Lion’s Mane is currently being researched for its possible role in supporting cognitive function, mood balance, and overall brain health.
How does Lion’s Mane help with cognitive function?
Lion’s Mane contains bioactive compounds known as hericenones and erinacines. These compounds have been studied for their potential role in stimulating the synthesis of nerve growth factor (NGF), a protein associated with the development and maintenance of brain cells. This research suggests possible implications for cognitive functions such as memory, learning, and concentration2.
What are the potential benefits of Lion’s Mane?
- Memory and Learning: Studies suggest Lion’s Mane may influence NGF (nerve growth factor) production, which may support neural growth and synaptic plasticity.
- Neurogenesis: Thought to play a role in the development of new neurons, potentially supporting brain repair and maintenance.
- Cognitive Ageing: Being studied for its potential to support healthy cognitive function over time.
- Mood and Emotional Balance: Some studies suggest possible benefits for mood regulation, though more research is needed.
What does the research say about Lion’s Mane mushroom?
University of Queensland study
In 2023, researchers at the University of Queensland’s Brain Institute studied compounds extracted from Lion’s Mane and their effect on brain cell growth3. Using super-resolution microscopy, they observed increased activity in growth cones, the structures that help neurons connect, suggesting improved neural communication. Dr Ramon Martinez-Marmol of UQ said that the finding suggests potential applications in treating neurodegenerative diseases3.
Clinical trials
A 12-week randomised, double-blind, placebo-controlled trial4 investigated the effects of Lion’s Mane on individuals with mild cognitive impairment. Participants who consumed Lion’s Mane supplements demonstrated improvements in cognitive functions, in memory and mental processing, as measured by the Mini-Mental State Examination (MMSE), compared with the placebo group. These effects appeared to decline once supplementation had ceased, prompting further investigation into duration and continuity of use.
Acute effects in healthy adults
A recent study published in Frontiers in Nutrition2 examined the immediate effects of a single dose of Lion’s Mane extract on cognitive performance in healthy young adults. While the overall cognitive and mood enhancements were not statistically significant, some participants showed improved performance in specific tasks, such as the pegboard test.
Considerations before use
While Lion’s Mane shows promise, it’s essential to consult with a healthcare professional before starting any new supplement regimen, especially for individuals with existing health conditions or those taking other medications.
References
2 https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2025.1405796/full
3 https://qbi.uq.edu.au/article/2023/02/mushrooms-magnify-memory-boosting-nerve-growth